Researchers provide evidence supporting requirement for gender-specific anti-inflammatory drugs

Possibly you know of the titles ‘Men come from Mars, women come from Venus’ or ‘Why men don’t listen and ladies can’t read maps’: just two many books and articles — some enlightening or amusing yet others irritating — that theorize about fundamental variations between women and men.

Inflammatory illnesses occur more often in females compared to men

One distinction between the sexes which should certainly be used seriously, however, continues to be of growing interest to doctors and pharmacists for several years. This is actually the distinction between the sexes in regards to inclination towards certain illnesses. “We all know, for instance, that inflammatory illnesses for example bronchial asthma, skin psoriasis or rheumatoid arthritis symptoms occur have sex in females compared to men,” states Prof. Oliver Werz from the Friedrich Schiller College Jena. The German pharmacist and the team, along with colleagues from Italia, Denmark, and Norway, have uncovered a substantial reason for these sex variations in the molecular level. In 2 high-profile publications within the ‘Journal of Clinical Analysis‘ and ‘Scientific Reports‘, they reveal the way the male sex hormone testosterone disrupts the biosynthesis of inflammatory substances, and furthermore reduces the potency of anti-inflammatory drugs. (DOI: 10.1172/JCI92885 and DOI: 10.1038/s41598-017-03696-8).

For this finish, they comprehensively examined and compared inflammatory processes in diverse animal models, but additionally in isolated immune cells in the bloodstream of men and women human contributors. It was thanks to a cell system coded in Prof. Werz’s laboratory, where the biochemical processes could be observed rich in precision over time-resolved microscopy. “We investigated the development of inflammatory substances, for example leukotrienes and prostaglandins, and checked out if the aftereffect of anti-inflammatory drugs differs in men and women cells,” explains Werz.

Testosterone can safeguard against inflammatory reactions

Not surprisingly, the result from the drugs under analysis was considerably more powerful within the female samples compared to a mans samples – in the end, the inflammatory process is a lot more pronounced in females. “However, these variations are totally abolished through the administration of testosterone,” states Dr Simona Pace, first author of both papers. Previous studies – including work by Prof. Werz’s team in Jena – have previously proven that testosterone can safeguard against inflammatory reactions. “However, we now have had the ability to throw light around the molecular mode of action and reveal that testosterone also influences the therapeutic aftereffect of drugs,” notes the postdoc in the Department for Pharmaceutical and Medical Chemistry from the College of Jena.

They found, first of all, the sex hormone directly disrupts leukotriene biosynthesis by blocking the required interaction between your “5-Lipoxygenase” and “FLAP” proteins. Next, they could prove the reduced leukotriene synthesis results in elevated levels of prostaglandins, which further promote inflammatory reactions. Which means that testosterone plays a vital role within the inflammatory process as well as in modulating the immune response.

With this particular work, they have once more provided specific evidence supporting the requirement for gender-specific medicine. “Anti-inflammatory substances which are appropriate for ladies might have merely a limited effect in males, and also the opposite could also be true,” concludes Prof. Werz. Treatment utilizing a single product in the medicine cabinet could, therefore, result in completely different amounts of success. This can be a proven fact that should clearly be looked at a lot more carefully later on in developing new drugs — specifically for treating inflammatory illnesses. Later on, this might even result in separate ‘his’ and ‘hers’ medicine cabinets.

Source:

Friedrich-Schiller-Universitaet Jena

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